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Warris LT, van den Akker EL, Bierings MB, et al

Adaptive immune dysregulation in PD appears to contribute to neuron loss: T cell infiltration and activation in the CNS correlates with more rapid disease progression

We treated with concentrations of SCLA compounds and derived alkyne probes (Supplementary Table 3) at which there was a strong senolytic effect but no cytotoxic effects in non-senescent cells (Fig