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Nature 500 , 422426 (2013)

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They proposed that the protein aggregates formed by SQSTM1 during systemic proteasome inhibition sequester mTOR and prevent its TFEB phosphorylation

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Noisy splicing driving mRNA isoform diversity in human cells may play a similar role [48]

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Interestingly, in a mouse model of coronary atherosclerosis, hemodynamic stress was shown to induce changes in sphingolipid metabolism that favored the production of S1P over ceramides, suggesting that blood vessels may be adaptative to stress [112]

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