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Telomeres shorten with aging, ultimately leading to extremely short telomeres, which impair the regenerative capacity of tissues and are considered one of the molecular markers of aging ( Telomerase, composed of a subunit called TERT and an associated RNA component known as Terc, can counterbalance the loss of telomeres by adding TTA GGG repeats to the ends of chromosomes in cells where it is typically present ( The effects of oxidative stress greatly affect telomeres, resulting in the buildup of DNA repair components known as telomere-associated lesions (TAFs)

Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

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