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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

No symptoms of chronic toxicity nor pathological organ changes were detected in rats fed 50 or 200 mg/daily of calcium pantothenate during 190 days nor in dogs (daily dose 50 mg/kg) and in monkeys (1 g daily for 45 kg body weight) fed for 6 months

Sturme MHJ, Nakayama J, Molenaar D, Murakami Y, Kunugi R, Fujii T, et al

Association between PI3K/AKT-mTOR and MYC Targets V2 activity (GSVA) and primitive / committed status