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Phosphodiesterase hydrolyzes cyclic AMP (cAMP) to 5-AMP, and by inhibiting phosphodiesterase, ATZ blocked the hydrolysis of cAMP to 5-AMP, resulting in increased cAMP levels ( in vitro studies, we conclude that ATZ exposure would lead to elevated cAMP levels due to its inhibition of phosphodiesterase

doi:10.7326/0003-4819-147-4-200708210-00175 Grtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW

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Physiological oxidative stress, which occurs at low levels, plays a role in redox signaling and regulation and is referred to as oxidative eustress