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Psychopharmacology 237 , 27392752 (2020)

The exact mechanisms of PACS may be multiply overlapping, several hypotheses have been proposed, including persistent viral existence in tissues, dysfunction of vascular endothelium and nervous system, reactivation of latent pathogens and gut microbiota alteration, long-lasting inflammation, and immune dysregulation (Davis et al., 2023)

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This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)

In ferroptosis, accumulation of intracellular iron ions triggers an elevated production of free radicals, potentially surpassing the cellular reductive capacity