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During recent decades, researchers turned to delivery systems based on natural and synthetic polymers and lipids because such liposomes possess valuable qualities, such as the incorporation of hydrophilic and hydrophobic drugs, and membrane penetration ( Application of Exosomes Providing a Novel View for Ferroptosis-Based Cancer Treatment Modified exosomes can be selectively used to deliver drugs to specific cells and present advantages, such as high effectiveness and reduced toxicity

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Strikingly, BCAAs metabolism displays paradoxical roles in diabetic pathophysiologygut dysbiosis-induced BCAA accumulation confers survival benefits in specific NSCLC-DM cohorts, yet effect directionality depends on individual metabotypes, necessitating longitudinal metabolomics to decode the DM-lung cancer risk continuum (Qian et al., 2022)