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For bodybuilders, the glucagon receptor activity is particularly compelling because it directly increases energy expenditure and preferentially targets visceral fat

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Moreover, IGF-1 can promote M2 microglial polarization via the inhibition of TLR4/NF-B signaling transduction and lead to the elevation of neuroprotection factors such as IL-10 and TGF- to attenuate microglia-mediated inflammation (Sun et al