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Lopez-Castejon G, Brough D (2011) Understanding the mechanism of IL-1 secretion

Consequently, higher glutathione reductase activity, which increases reduced glutathione levels, seems to be associated with better health and increased life span.56 Paralleling the fact that higher glutathione levels are associated with better health and increased longevity are studies reporting that lower glutathione levels are associated with chronic diseases and that glutathione levels are a biomarker that can be used to monitor the severity and progress of diseases.57 In fact, lower glutathione levels are associated with a wide range of chronic degenerative diseases such as arthritis, HIV/AIDS, various cancers, cataracts, diabetes, heart disease, leukemia, kidney failure, hearing loss, macular degeneration, and urinary, GI, and musculoskeletal diseases.58,59,60,61 The evidence linking glutathione levels with greater health and increased longevity are causing some researchers to proclaim that glutathione is a reliable biomarker of aging

The development of these novel molecular entities and O&NS events may additionally contribute to atherosclerotic mechanisms, including IgG-mediated autoimmune responses targeting oxidized low-density lipoprotein [139]

Table 1 The most important clinical studies with exogenous antioxidants in patients with AD

and A.B.) conducted the searches and one (F.D.) checked for duplicates