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Mitchell, M.C., D.S

Melatonin in cryopreservation media improves transplantation efficiency of frozen-thawed spermatogonial stem cells into testes of azoospermic mice

2.2 Data synthesis Eligible studies were categorized by cytokine type, study model (clinical/preclinical), and affected molecular pathways

M.WilkinsonH.KohlerM.SchaefferJ

Key gaps include limited human RCTs for mechanism validation, overlooked microbiota-nutrient bidirectional interactions, and lack of personalized strategies