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Glial indoleamine 2,3-dioxygenase (a tryptophan metabolizing enzyme) is up-regulated, resulting in greater production of neurotoxic kynurenine metabolites and quinolinic acid (QA) (102, 209, 212, 213)

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Luciferase reporter gene assay STAT3 transcription was measured using pGL4.47[luc2P/SIE/Hygro] (Promega, Madison, WI, USA) according to the manufacturers instructions

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Both forms ultimately provide vitamin B activity, but hydroxocobalamins longer duration in the body means injections can be given less frequently in maintenance therapy