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Yet there were no reported cases until the arrival of British troops during the second world war, shortly after which time an epidemic of MS broke out, leading the prominent epidemiologist John Kurtzke to conclude that MS might be a transmissible infectious disease (Kurtzke, 1993)

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421,422,423 Structural and functional changes within the somatosensory system, along with maladaptive responses in the CNS and PNS, contribute to the mechanisms underlying PDPN (Fig