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Ohanian M, Rozovski U, Kantarjian HM, Loghavi S, Zuang Z, Abruzzo L, Huh YO, Garcia-Manero G, Ravandi F, Andreeff M , Kornblau S, Borthakur G, Nguyen M, Hu P, Medeiros J, Nogueras-Gonzalez GM, Huang X, Estrov Z, Bueso-Ramos CE, Cortes JE

Analogously, KRAS inhibitors (Sotorasib) targeting the G12C mutation and eprenetapopt (APR-246), a novel drug for Tp53 -mutant MDS and AML, both are representatives of this molecules

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These challenges include curcumins poor solubility in gastrointestinal fluids, which hinders its passage through the mucus layer and subsequent absorption by epithelial cells