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It has been shown that repeated exposure to an addictive substance has modified the quantity or type of proteins expressed in specific brain areas (21)

Actigraphy: Around-the-clock activity and resting states are registered in the home environment for a longer period of time, thus enabling an estimation of total sleep time, sleep efficiency, sleep latency and sleep fragmentation, as well as screening for circadian rhythm disorders

Menopause Diet: Key Concepts and Nutritional Needs The hormonal upheaval during menopause, particularly the decline in estrogen, can increase the risk of osteoporosis, cardiovascular disease, and altered metabolic states

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S1A) and 0.70 for carrier/control comparisons (Supplemental Information, Fig