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To answer these questions, well need better tools, such as single-cell genomic profiling for detecting mutations and their formation timing, and long-term in vivo models that can capture these transitions as they unfold

Beigelman 6 , Sushmita Chanda 6 , Tse-I Lin 6 and Matthew McClure 6 , (1)Nanfang Hospital of Southern Medical University, (2)The First Hospital of Jilin University, (3)State Key Laboratory of Liver Research, the University of Hong Kong, Hong Kong SAR, (4)Faculty of Medicine, University of Auckland, (5)Institute of Liver Studies, King's College Hospital, (6)Aligos Therapeutics, Inc

doi: 10.1016/j.ghir.2014.03.004