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Skyla Gould, Isabella Munns and Pippa Berry

tablets rely on gut function

The data from human endothelial cultures are unlikely to address a complex in vivo issue that involves multiple cell-types

Altitude hypobaric hypoxia leading to hypoxemia triggers high-altitude sickness, although the precise mechanisms remain poorly understood

Nonetheless, oral drug delivery faces substantial challenges, such as reduced drug stability due to gastrointestinal physiological barriers, and difficulty in targeting specific inflamed regions of the colon [51, 52]