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Interestingly, there is emerging evidence that TCAs may improve liver fibrosis and reduce portal hypertensive complications, a potential dual benefit that warrants further investigation [55, 56]

These molecules can further induce various transcription factors, like NF-B, STAT, p53, and activator protein-1 (AP-1) [9]

Suppression of tumor growth by senescence in virally transformed human fibroblasts

More importantly, by restoring mitochondrial integrity via overexpressing hHsp27, the development of mechanical and cold allodynia was completely prevented in paclitaxel-treated or vincristine-treated hHsp27 overexpressing mice (Chine et al., 2019a,b)