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Ethyl acetate extract of herpetospermum pedunculosum alleviates -naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats

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Disulfide-linked polymerdrug conjugates and nanocarriers engineered for GSH-triggered drug release have shown favorable safety and preliminary efficacy profiles, highlighting the feasibility of translating redox-responsive strategies into clinical practice [120]

In studies targeting ferroptosis in HCC, HNF4A was found to transcriptionally regulate such as STMN1, CAPG, and RRM2 under the action of erastin, and to increase GSH production and thus inhibit ferroptosis by promoting PSAT1