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Last but not least, by reducing the dose and avoiding systemic distribution, nasal delivery of GLP-1 drugs should alleviate gastrointestinal and other adverse events, offering a promising approach for maximizing the therapeutic effects GLP-1 drugs with potentially increased compliance and safety

Moreover, generation of oxygen-free radicals, e.g., the hydroxyl radical and then hydrogen peroxide, resulting from redox cycling of 4-OHE 2 to the E 2 3,4Q and back conversion to 4-OHE 2 , lead to oxidative modification of DNA

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On the other hand, increased levels of taurine were reported in retinoblastoma, glioblastoma, and medulloblastoma in vivo [53, 54]

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF- activation